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KMID : 1134820180470050503
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Journal of the Korean Society of Food Science and Nutrition
2018 Volume.47 No. 5 p.503 ~ p.511
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Effects of Coumarin Derivatives on Visceral Fat Mass and Lipid Metabolism in Ovariectomized Mice
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Ham Ju-Ri
Lee Mi-Kyung
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Abstract
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This study investigated the effects of coumarin derivatives (herniarin, osthole and bergapten) on body fat mass and lipid metabolism in ovariectomized (OVX) mice. Female C3H/HeN mice were divided into five groups: negative control group (Sham), OVX and OVX mice were fed with a diet containing 0.02% (w/w) herniarin, osthole or bergapten for 6 weeks. Visceral fat (cervical, abdominal, and mesenteric white adipose tissue) mass increased in the OVX group compared with the Sham group; however, herniarin supplementation significantly reduced visceral fat mass. The size of cervical adipocytes decreased in all coumarin supplemented groups relative to the OVX group. Furthermore, three coumarin derivatives significantly down-regulated expression of lipogenic genes such as fatty acid synthase, stearoyl-coenzyme A desaturase-1 and diacylglycerol O-acyltransferase 2 in adipose tissue. Osthole and bergapten supplementation significantly decreased hepatic lipid (triglyceride and free fatty acid) contents compared with the OVX group. Osthole supplementation significantly decreased fatty acid synthase and phosphatidate phosphohydrolase activity compared with the OVX group, whereas bergapten significantly increased hepatic fatty acid oxidation activity. Overall, these results suggest that herniarin, osthole or bergapten may be useful natural agents for the treatment or prevention of postmenopausal adiposity and lipid dysmetabolism.
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KEYWORD
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adiposity, coumarin derivatives, hepatic lipid, ovariectomy, visceral fat mass
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